Pulsed dose oxygen delivery system

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Short report Evaluation of pulsed dose oxygen delivery during exercise in patients with severe chronic obstructive pulmonary disease

Background—Oxygen conserving devices may lead to substantial increases in the duration of oxygen provided. A study was undertaken to compare the performance of a pulsed dose oxygen delivery (PDOD) system with continuous flow oxygen or air during a maximal walking test. Methods—Fourteen patients with chronic obstructive pulmonary disease (COPD) and arterial oxygen desaturation on exercise (mean ...

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Modern drug delivery aims to develop drug delivery systems that are able to meet specific therapeutic requirements. Whereas sustained drug release aims to maintain a constant drug level within the body, pulsed drug delivery intends to release the drug rapidly within a short period of time, as a result of a biological or external trigger, after a specific lag time. This editorial highlights some...

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Towards an Implantable Pulsed Mode Electrolytic Drug Delivery System

This work presents a prototype of an implantable drug delivery system that delivers pulsed doses of a low solubility drug by pulling bodily fluid into a reservoir with the drug in solid form, allowing the drug to dissolve to its maximum co ncentration, and then ejecting the drug laced fluid back into the tissue. The cyclical actuation of the drug delivery sy stem is performed using an electroly...

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Comparison of pulsed versus continuous oxygen delivery using realistic adult nasal airway replicas

BACKGROUND Portable oxygen concentrators (POCs) typically include pulse flow (PF) modes to conserve oxygen. The primary aims of this study were to develop a predictive in vitro model for inhaled oxygen delivery using a set of realistic airway replicas, and to compare PF for a commercial POC with steady flow (SF) from a compressed oxygen cylinder. METHODS Experiments were carried out using a s...

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ژورنال

عنوان ژورنال: Thorax

سال: 1999

ISSN: 0040-6376

DOI: 10.1136/thx.54.8.750a